Methadone and valproate combination effect on acquisition and expression of morphine dependence and tolerance in male mice
Authors
Abstract:
Abstract Background and Objective: According to the issue of dependence and tolerance in addicted patients, the inefficiency of existing treatments and the new recommendation for drug combination therapy for diseases in modern pharmacology, the present study examined the effect of methadone and valproate combination on morphine dependence and tolerance. Materials and Methods: Ninety-eight male mice were divided into the following groups: saline, morphine, methadone, valproate, and three groups of valproate+methadone, i.e. 1 to 1, 2 to 1 and 1 to 2 ratios. Except for the saline group, the others received escalating dose of morphine for 8 consecutive days. In acquisition group, drugs were injected for 30 minutes before morphine administration. In expression group, the drugs were used only at 8th day (test day). Morphine tolerance was measured by tail immersion test and for dependence assessment, naloxone-induced withdrawal signs was evaluated. Results: Jumping behavior as a main sign of dependence in both acquisition and expression significantly reduced in methadone1+valproate2 treatment group. Also, acquisition and expression of tolerance significantly decreased in valproate and methadone1+valproate2 more than other groups. Conclusion: Our results show that methadone and valproate combination treatment could probably reduce tolerance and dependence more than single valproate or methadone treatments.
similar resources
Methadone and haloperidol combination effect on the acquisition and expression of morphine tolerance and dependence in male mice
Background and Objective: Today, opioids are used to control and relieve acute and chronic pain. However, the incidence of both tolerance and dependence phenomena for these drugs is a major problem. So, in this study, the combination effect of haloperidol and methadone on the acquisition and expression of morphine dependence and tolerance was examined. Materials and Methods: Ninety-eight mic...
full textmethadone and valproate combination effect on acquisition and expression of morphine dependence and tolerance in male mice
abstract background and objective: according to the issue of dependence and tolerance in addicted patients, the inefficiency of existing treatments and the new recommendation for drug combination therapy for diseases in modern pharmacology, the present study examined the effect of methadone and valproate combination on morphine dependence and tolerance. materials and methods: ninety-eight male ...
full textmethadone and haloperidol combination effect on the acquisition and expression of morphine tolerance and dependence in male mice
background and objective: today, opioids are used to control and relieve acute and chronic pain. however, the incidence of both tolerance and dependence phenomena for these drugs is a major problem. so, in this study, the combination effect of haloperidol and methadone on the acquisition and expression of morphine dependence and tolerance was examined. materials and methods: ninety-eight mic...
full textThe effect of methadone and haloperidol combination on anxiety induced by morphine withdrawal in male mice
Background and Objective: Regarding inefficiency of common drugs used for alleviation of anxiety due to narcotics withdrawal, the present study was evaluated methadone and haloperidol co-drugs therapy on anxiety due to morphine withdrawal. Materials and Methods: Ninety eight NMRI male mice were divided into acute and chronic experimental groups. Then, each group was divided into 7 subgroups: sa...
full textبررسی اثر ترکیبی داروهای متادون و والپروات بر اکتساب و بیان وابستگی و تحمل به مورفین در موشهای سوری نر
Background and Objective: According to the problem of dependence and tolerance in addicted patients, the inefficiency of existing treatments and the new sciences recommendation of drug combination therapy for diseases in modern pharmacology, the present study examined the effects of methadone and valproate combination on morphine tolerance and dependence. Materials and Methods: Nine...
full textThe effect of ketamine and midazolam on morphine dependence and tolerance in mice
The aim of this study was to investigate the effect of ketamine and midazolam on preventing the development of morphine tolerance and dependence and withdrawal syndrome in mice. In the present study different groups of mice were received morphine (50 mg/kg, s.c.), morphine (50 mg/kg, s.c.) + ketamine (25, 50, 75 mg/kg, i.p.) , morphine (50 mg/kg , s.c.) + midazolam (0.5, 1, 2 mg/kg, i.p.) , mor...
full textMy Resources
Journal title
volume 2 issue 1
pages 15- 22
publication date 2013-02-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023